Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA

SIMPLE SUMMARY: Synovial sarcoma is a soft-tissue sarcoma that lacks effective systemic therapy and carries poor prognosis due to frequent late local recurrence and metastases. The cancer is known to be driven in part by increased expression of the pro-survival protein BCL-2. Surprisingly, synovial...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Fairchild, Carter K., Floros, Konstantinos V., Jacob, Sheeba, Coon, Colin M., Puchalapalli, Madhavi, Hu, Bin, Harada, Hisashi, Dozmorov, Mikhail G., Koblinski, Jennifer E., Smith, Steven C., Domson, Gregory, Leverson, Joel D., Souers, Andrew J., Takebe, Naoko, Ebi, Hiromichi, Faber, Anthony C., Boikos, Sosipatros A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150384/
https://ncbi.nlm.nih.gov/pubmed/34065859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13102310
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