Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA

SIMPLE SUMMARY: Synovial sarcoma is a soft-tissue sarcoma that lacks effective systemic therapy and carries poor prognosis due to frequent late local recurrence and metastases. The cancer is known to be driven in part by increased expression of the pro-survival protein BCL-2. Surprisingly, synovial...

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Publicat a:Cancers (Basel)
Autors principals: Fairchild, Carter K., Floros, Konstantinos V., Jacob, Sheeba, Coon, Colin M., Puchalapalli, Madhavi, Hu, Bin, Harada, Hisashi, Dozmorov, Mikhail G., Koblinski, Jennifer E., Smith, Steven C., Domson, Gregory, Leverson, Joel D., Souers, Andrew J., Takebe, Naoko, Ebi, Hiromichi, Faber, Anthony C., Boikos, Sosipatros A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150384/
https://ncbi.nlm.nih.gov/pubmed/34065859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13102310
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