Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma

High-risk neuroblastoma is often distinguished by amplification of MYCN and loss of differentiation potential. We performed high-throughput drug screening of epigenetic-targeted therapies across a large and diverse tumor cell line panel and uncovered the hypersensitivity of neuroblastoma cells to GS...

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Pubblicato in:Sci Transl Med
Autori principali: Lochmann, Timothy L., Powell, Krista M., Ham, Jungoh, Floros, Konstantinos V., Heisey, Daniel A. R., Kurupi, Richard I. J., Calbert, Marissa L., Ghotra, Maninderjit S., Greninger, Patricia, Dozmorov, Mikhail, Gowda, Madhu, Souers, Andrew J., Reynolds, C. Patrick, Benes, Cyril H., Faber, Anthony C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200133/
https://ncbi.nlm.nih.gov/pubmed/29769286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao4680
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