Venetoclax is effective in small cell lung cancers with high BCL-2 expression

PURPOSE: Small cell lung cancer (SCLC) is an often-fatal neuroendocrine carcinoma usually presenting as extensive disease, carrying a 3% five-year survival. Despite notable advances in SCLC genomics, new therapies remain elusive, largely due to a lack of druggable targets. EXPERIMENTAL DESIGN: We us...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Lochmann, Timothy L., Floros, Konstantinos V., Naseri, Mitra, Powell, Krista M., Cook, Wade, March, Ryan J., Stein, Giovanna T., Greninger, Patricia, Maves, Yuki Kato, Saunders, Laura R., Dylla, Scott J., Costa, Carlotta, Boikos, Sosipatros A., Leverson, Joel D., Souers, Andrew J., Krystal, Geoffrey W., Harada, Hisashi, Benes, Cyril H., Faber, Anthony C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771805/
https://ncbi.nlm.nih.gov/pubmed/29118061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1606
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