Venetoclax is effective in small cell lung cancers with high BCL-2 expression

PURPOSE: Small cell lung cancer (SCLC) is an often-fatal neuroendocrine carcinoma usually presenting as extensive disease, carrying a 3% five-year survival. Despite notable advances in SCLC genomics, new therapies remain elusive, largely due to a lack of druggable targets. EXPERIMENTAL DESIGN: We us...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Lochmann, Timothy L., Floros, Konstantinos V., Naseri, Mitra, Powell, Krista M., Cook, Wade, March, Ryan J., Stein, Giovanna T., Greninger, Patricia, Maves, Yuki Kato, Saunders, Laura R., Dylla, Scott J., Costa, Carlotta, Boikos, Sosipatros A., Leverson, Joel D., Souers, Andrew J., Krystal, Geoffrey W., Harada, Hisashi, Benes, Cyril H., Faber, Anthony C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771805/
https://ncbi.nlm.nih.gov/pubmed/29118061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1606
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