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Found in translation: how preclinical research is guiding the clinical development of the BCL-2-selective inhibitor venetoclax

Since the discovery of apoptosis as a form of programmed cell death, targeting the apoptosis pathway to induce cancer cell death has been a high priority goal for cancer therapy. After decades of effort, drug discovery scientists have succeeded in generating small-molecule inhibitors of antiapoptoti...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Leverson, Joel D., Sampath, Deepak, Souers, Andrew J., Rosenberg, Saul H., Fairbrother, Wayne J., Amiot, Martine, Konopleva, Marina, Letai, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728441/
https://ncbi.nlm.nih.gov/pubmed/29146569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0797
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