Blastic plasmacytoid dendritic cell neoplasm is dependent on BCL-2 and sensitive to venetoclax

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with dismal outcomes for which no standard therapy exists. We found that primary BPDCN cells were dependent on the anti-apoptotic protein BCL-2 and were uniformly sensitive to the BCL-2 inhibitor venetoclax,...

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Publicado no:Cancer Discov
Main Authors: Montero, Joan, Stephansky, Jason, Cai, Tianyu, Griffin, Gabriel K., Cabal-Hierro, Lucia, Togami, Katsuhiro, Hogdal, Leah J., Galinsky, Ilene, Morgan, Elizabeth A., Aster, Jon C., Davids, Matthew S., LeBoeuf, Nicole R., Stone, Richard M., Konopleva, Marina, Pemmaraju, Naveen, Letai, Anthony, Lane, Andrew A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296248/
https://ncbi.nlm.nih.gov/pubmed/27986708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0999
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