Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma

High-risk neuroblastoma is often distinguished by amplification of MYCN and loss of differentiation potential. We performed high-throughput drug screening of epigenetic-targeted therapies across a large and diverse tumor cell line panel and uncovered the hypersensitivity of neuroblastoma cells to GS...

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Publicado no:Sci Transl Med
Main Authors: Lochmann, Timothy L., Powell, Krista M., Ham, Jungoh, Floros, Konstantinos V., Heisey, Daniel A. R., Kurupi, Richard I. J., Calbert, Marissa L., Ghotra, Maninderjit S., Greninger, Patricia, Dozmorov, Mikhail, Gowda, Madhu, Souers, Andrew J., Reynolds, C. Patrick, Benes, Cyril H., Faber, Anthony C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200133/
https://ncbi.nlm.nih.gov/pubmed/29769286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao4680
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