Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

Genetic variation within the factor H–related (FHR) genes is associated with the complement-mediated kidney disease, C3 glomerulopathy (C3G). There is no definitive treatment for C3G, and a significant proportion of patients develop end-stage renal disease. The prototypical example is CFHR5 nephropa...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Malik, Talat H., Gitterman, Daniel P., Lavin, Deborah P., Lomax-Browne, Hannah J., Hiemeyer, E. Christina, Moran, Linda B., Boroviak, Katharina, Cook, H. Terence, Gilmore, Alyssa C., Mandwie, Mawj, Ahmad, Amina, Alexander, Ian E., Logan, Grant J., Marchbank, Kevin J., Bradley, Allan, Pickering, Matthew C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2021
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020653/
https://ncbi.nlm.nih.gov/pubmed/33753502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022722118
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