Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

Genetic variation within the factor H–related (FHR) genes is associated with the complement-mediated kidney disease, C3 glomerulopathy (C3G). There is no definitive treatment for C3G, and a significant proportion of patients develop end-stage renal disease. The prototypical example is CFHR5 nephropa...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Malik, Talat H., Gitterman, Daniel P., Lavin, Deborah P., Lomax-Browne, Hannah J., Hiemeyer, E. Christina, Moran, Linda B., Boroviak, Katharina, Cook, H. Terence, Gilmore, Alyssa C., Mandwie, Mawj, Ahmad, Amina, Alexander, Ian E., Logan, Grant J., Marchbank, Kevin J., Bradley, Allan, Pickering, Matthew C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020653/
https://ncbi.nlm.nih.gov/pubmed/33753502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022722118
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