Gain-of-function factor H–related 5 protein impairs glomerular complement regulation resulting in kidney damage

Genetic variation within the factor H–related (FHR) genes is associated with the complement-mediated kidney disease, C3 glomerulopathy (C3G). There is no definitive treatment for C3G, and a significant proportion of patients develop end-stage renal disease. The prototypical example is CFHR5 nephropa...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Malik, Talat H., Gitterman, Daniel P., Lavin, Deborah P., Lomax-Browne, Hannah J., Hiemeyer, E. Christina, Moran, Linda B., Boroviak, Katharina, Cook, H. Terence, Gilmore, Alyssa C., Mandwie, Mawj, Ahmad, Amina, Alexander, Ian E., Logan, Grant J., Marchbank, Kevin J., Bradley, Allan, Pickering, Matthew C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020653/
https://ncbi.nlm.nih.gov/pubmed/33753502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022722118
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