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Whsc1 links pluripotency exit with mesendoderm specification
How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here we show that the chromatin-related factor Whsc1 (Nsd2, MMSET) has a dual role in pluripotency exit and germ layer specification of embryonic stem cells (ESCs). Upon induction of differ...
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| Publicat a: | Nat Cell Biol |
|---|---|
| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8020485/ https://ncbi.nlm.nih.gov/pubmed/31235934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0342-1 |
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