Whsc1 links pluripotency exit with mesendoderm specification

How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here we show that the chromatin-related factor Whsc1 (Nsd2, MMSET) has a dual role in pluripotency exit and germ layer specification of embryonic stem cells (ESCs). Upon induction of differ...

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Udgivet i:Nat Cell Biol
Main Authors: Tian, Tian V., Di Stefano, Bruno, Stik, Grégoire, Vila-Casadesús, Maria, Sardina, José Luis, Vidal, Enrique, Dasti, Alessandro, Morales, Carolina Segura, De Andres Aguayo, Luisa, Gomez, Antonio, Goldmann, Johanna, Jaenisch, Rudolf, Graf, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020485/
https://ncbi.nlm.nih.gov/pubmed/31235934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0342-1
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