PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial function. mTOR inhibition with rapamycin attenuates disease progression in a mouse model of Leigh syndrome (Ndufs4 KO mouse); however, the mechanism of rescue is unknown. Here we identify PKC downregulation as a key...

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Udgivet i:Nat Metab
Main Authors: Martin-Perez, Miguel, Grillo, Anthony S., Ito, Takashi K., Valente, Anthony S., Han, Jeehae, Entwisle, Samuel W., Huang, Heather Z., Kim, Dayae, Yajima, Masanao, Kaeberlein, Matt, Villén, Judit
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017771/
https://ncbi.nlm.nih.gov/pubmed/33324011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-00319-x
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