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PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial function. mTOR inhibition with rapamycin attenuates disease progression in a mouse model of Leigh syndrome (Ndufs4 KO mouse); however, the mechanism of rescue is unknown. Here we identify PKC downregulation as a key...
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| Publicado no: | Nat Metab |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8017771/ https://ncbi.nlm.nih.gov/pubmed/33324011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-00319-x |
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