PAK4 suppresses motor neuron degeneration in hSOD1(G93A)‐linked amyotrophic lateral sclerosis cell and rat models

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons (MN). CREB pathway‐mediated inhibition of apoptosis contributes to neuron protection, and PAK4 activates CREB signalling in diverse cell types. This study aimed...

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Vydáno v:Cell Prolif
Hlavní autoři: Cong, Chaohua, Liang, Weiwei, Zhang, Chunting, Wang, Ying, Yang, Yueqing, Wang, Xudong, Wang, Shuyu, Huo, Di, Wang, Hongyong, Wang, Di, Feng, Honglin
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016643/
https://ncbi.nlm.nih.gov/pubmed/33615605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.13003
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