PAK4 suppresses motor neuron degeneration in hSOD1(G93A)‐linked amyotrophic lateral sclerosis cell and rat models

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons (MN). CREB pathway‐mediated inhibition of apoptosis contributes to neuron protection, and PAK4 activates CREB signalling in diverse cell types. This study aimed...

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Publicat a:Cell Prolif
Autors principals: Cong, Chaohua, Liang, Weiwei, Zhang, Chunting, Wang, Ying, Yang, Yueqing, Wang, Xudong, Wang, Shuyu, Huo, Di, Wang, Hongyong, Wang, Di, Feng, Honglin
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016643/
https://ncbi.nlm.nih.gov/pubmed/33615605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.13003
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