PAK4 suppresses motor neuron degeneration in hSOD1(G93A)‐linked amyotrophic lateral sclerosis cell and rat models

OBJECTIVES: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons (MN). CREB pathway‐mediated inhibition of apoptosis contributes to neuron protection, and PAK4 activates CREB signalling in diverse cell types. This study aimed...

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Dettagli Bibliografici
Pubblicato in:Cell Prolif
Autori principali: Cong, Chaohua, Liang, Weiwei, Zhang, Chunting, Wang, Ying, Yang, Yueqing, Wang, Xudong, Wang, Shuyu, Huo, Di, Wang, Hongyong, Wang, Di, Feng, Honglin
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016643/
https://ncbi.nlm.nih.gov/pubmed/33615605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.13003
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