A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests

MOTIVATION: Analysis of rare variants in family-based studies remains a challenge. Transmission-based approaches provide robustness against population stratification, but the evaluation of the significance of test statistics based on asymptotic theory can be imprecise. Also, power will depend heavil...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Bioinformatics
Main Authors: Hecker, Julian, Townes, F William, Kachroo, Priyadarshini, Laurie, Cecelia, Lasky-Su, Jessica, Ziniti, John, Cho, Michael H, Weiss, Scott T, Laird, Nan M, Lange, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Original Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016468/
https://ncbi.nlm.nih.gov/pubmed/33367522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa1055
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares