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A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests
MOTIVATION: Analysis of rare variants in family-based studies remains a challenge. Transmission-based approaches provide robustness against population stratification, but the evaluation of the significance of test statistics based on asymptotic theory can be imprecise. Also, power will depend heavil...
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| 出版年: | Bioinformatics |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8016468/ https://ncbi.nlm.nih.gov/pubmed/33367522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa1055 |
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