A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests

MOTIVATION: Analysis of rare variants in family-based studies remains a challenge. Transmission-based approaches provide robustness against population stratification, but the evaluation of the significance of test statistics based on asymptotic theory can be imprecise. Also, power will depend heavil...

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Bibliografski detalji
Izdano u:Bioinformatics
Glavni autori: Hecker, Julian, Townes, F William, Kachroo, Priyadarshini, Laurie, Cecelia, Lasky-Su, Jessica, Ziniti, John, Cho, Michael H, Weiss, Scott T, Laird, Nan M, Lange, Christoph
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
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Original Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016468/
https://ncbi.nlm.nih.gov/pubmed/33367522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa1055
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