Characterizing the molecular regulation of inhibitory immune checkpoints with multi-modal single-cell screens.

The expression of inhibitory immune checkpoint molecules such as PD-L1 is frequently observed in human cancers and can lead to the suppression of T cell-mediated immune responses. Here, we apply ECCITE-seq, a technology which combines pooled CRISPR screens with single-cell mRNA and surface protein m...

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Udgivet i:Nat Genet
Main Authors: Papalexi, Efthymia, Mimitou, Eleni P., Butler, Andrew W., Foster, Samantha, Bracken, Bernadette, Mauck, William M., Wessels, Hans-Hermann, Hao, Yuhan, Yeung, Bertrand Z., Smibert, Peter, Satija, Rahul
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011839/
https://ncbi.nlm.nih.gov/pubmed/33649593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00778-2
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