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Characterizing the molecular regulation of inhibitory immune checkpoints with multi-modal single-cell screens.
The expression of inhibitory immune checkpoint molecules such as PD-L1 is frequently observed in human cancers and can lead to the suppression of T cell-mediated immune responses. Here, we apply ECCITE-seq, a technology which combines pooled CRISPR screens with single-cell mRNA and surface protein m...
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| Publicado no: | Nat Genet |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8011839/ https://ncbi.nlm.nih.gov/pubmed/33649593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00778-2 |
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