Characterizing the molecular regulation of inhibitory immune checkpoints with multi-modal single-cell screens.

The expression of inhibitory immune checkpoint molecules such as PD-L1 is frequently observed in human cancers and can lead to the suppression of T cell-mediated immune responses. Here, we apply ECCITE-seq, a technology which combines pooled CRISPR screens with single-cell mRNA and surface protein m...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Genet
Autors principals: Papalexi, Efthymia, Mimitou, Eleni P., Butler, Andrew W., Foster, Samantha, Bracken, Bernadette, Mauck, William M., Wessels, Hans-Hermann, Hao, Yuhan, Yeung, Bertrand Z., Smibert, Peter, Satija, Rahul
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011839/
https://ncbi.nlm.nih.gov/pubmed/33649593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00778-2
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars