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Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer

Genome-wide association studies (GWAS) explore the genetic causes of complex diseases. However, classical approaches ignore the biological context of the genetic variants and genes under study. To address this shortcoming, one can use biological networks, which model functional relationships, to sea...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Climente-González, Héctor, Lonjou, Christine, Lesueur, Fabienne, Stoppa-Lyonnet, Dominique, Andrieu, Nadine, Azencott, Chloé-Agathe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009366/
https://ncbi.nlm.nih.gov/pubmed/33735170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008819
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