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The biological effects and clinical implications of BRCA mutations: where do we go from here?
BRCA1 and BRCA2 are tumour-suppressor genes encoding proteins that are essential for the repair of DNA double-strand breaks by homologous recombination (HR). Cells that lack either BRCA1 or BRCA2 repair these lesions by alternative, more error-prone mechanisms. Individuals carrying germline pathogen...
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| Publicado en: | Eur J Hum Genet |
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| Autor principal: | |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5141575/ https://ncbi.nlm.nih.gov/pubmed/27514841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.93 |
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