Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family

BACKGROUND AND AIMS: Hypercholesterolemia confers susceptibility to cardiovascular disease (CVD). Both serum total cholesterol (TC) and LDL-cholesterol (LDL-C) exhibit a strong genetic component (heritability estimates 0.41–0.50). However, a large part of this heritability cannot be explained by the...

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Detalhes bibliográficos
Publicado no:Atherosclerosis
Main Authors: Nikkola, Elina, Ko, Arthur, Alvarez, Marcus, Cantor, Rita M., Garske, Kristina, Kim, Elliot, Gee, Stephanie, Rodriguez, Alejandra, Muxel, Reinhard, Matikainen, Niina, Söderlund, Sanni, Motazacker, Mahdi M., Borén, Jan, Lamina, Claudia, Kronenberg, Florian, Schneider, Wolfgang J., Palotie, Aarno, Laakso, Markku, Taskinen, Marja-Riitta, Pajukanta, Päivi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698088/
https://ncbi.nlm.nih.gov/pubmed/28772107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2017.07.024
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