Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in humans

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. The transmembrane 6 superfamily member 2 (TM6SF2) E167K genetic variant associates with NAFLD and with reduced plasma triglyceride levels in humans. However, the molecular mechanisms underlying these association...

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Publicat a:JCI Insight
Autors principals: Borén, Jan, Adiels, Martin, Björnson, Elias, Matikainen, Niina, Söderlund, Sanni, Rämö, Joel, Ståhlman, Marcus, Ripatti, Pietari, Ripatti, Samuli, Palotie, Aarno, Mancina, Rosellina M., Hakkarainen, Antti, Romeo, Stefano, Packard, Chris J., Taskinen, Marja-Riitta
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819740/
https://ncbi.nlm.nih.gov/pubmed/33170809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144079
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