Impact of cytosine methylation on DNA binding specificities of human transcription factors

The majority of CpG dinucleotides in the human genome are methylated at cytosine bases. However, active gene regulatory elements are generally hypomethylated relative to their flanking regions, and the binding of some transcription factors (TFs) is diminished by methylation of their target sequences...

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Udgivet i:Science
Main Authors: Yin, Yimeng, Morgunova, Ekaterina, Jolma, Arttu, Kaasinen, Eevi, Sahu, Biswajyoti, Khund-Sayeed, Syed, Das, Pratyush K., Kivioja, Teemu, Dave, Kashyap, Zhong, Fan, Nitta, Kazuhiro R., Taipale, Minna, Popov, Alexander, Ginno, Paul A., Domcke, Silvia, Yan, Jian, Schübeler, Dirk, Vinson, Charles, Taipale, Jussi
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009048/
https://ncbi.nlm.nih.gov/pubmed/28473536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaj2239
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