Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction

DNA damage activates cell cycle checkpoint proteins ATR and CHK1 to arrest cell cycle progression, providing time for repair and recovery. Consequently, inhibitors of ATR (ATRi) and CHK1 (CHK1i) enhance damage-induced cell death. Intriguingly, both CHK1i and ATRi alone elicit cytotoxicity in some ce...

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Vydáno v:Sci Rep
Hlavní autoři: Ditano, Jennifer P., Donahue, Katelyn L., Tafe, Laura J., McCleery, Charlotte F., Eastman, Alan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007816/
https://ncbi.nlm.nih.gov/pubmed/33782497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86490-x
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