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Conformational Plasticity in Human Heme-Based Dioxygenases
Human indoleamine 2,3-dioxygenase 1 (hIDO1) and human tryptophan dioxygenase (hTDO) are two important heme proteins that degrade the essential amino acid, L-tryptophan (Trp), along the kynurenine pathway. The two enzymes share a similar active site structure and an analogous catalytic mechanism, but...
Enregistré dans:
| Publié dans: | J Am Chem Soc |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8000349/ https://ncbi.nlm.nih.gov/pubmed/33373218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c09970 |
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