Evidence for a ferryl intermediate in a heme-based dioxygenase

In contrast to the wide spectrum of cytochrome P450 monooxygenases, there are only 2 heme-based dioxygenases in humans: tryptophan dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO). hTDO and hIDO catalyze the same oxidative ring cleavage reaction of L-tryptophan to N-formyl kynurenine, the i...

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Bibliographic Details
Main Authors: Lewis-Ballester, Ariel, Batabyal, Dipanwita, Egawa, Tsuyoshi, Lu, Changyuan, Lin, Yu, Marti, Marcelo A., Capece, Luciana, Estrin, Dario A., Yeh, Syun-Ru
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765089/
https://ncbi.nlm.nih.gov/pubmed/19805032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906655106
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