Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants

Ras is regulated by a specific guanine nucleotide exchange factor Son of Sevenless (SOS), which facilitates the exchange of inactive, GDP-bound Ras with GTP. The catalytic activity of SOS is also allosterically modulated by an active Ras (Ras–GTP). However, it remains poorly understood how oncogenic...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Moghadamchargari, Zahra, Shirzadeh, Mehdi, Liu, Chang, Schrecke, Samantha, Packianathan, Charles, Russell, David H., Zhao, Minglei, Laganowsky, Arthur
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000204/
https://ncbi.nlm.nih.gov/pubmed/33723061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022403118
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