Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry

Mutations in RAS are associated with many different cancers and have been a therapeutic target for more than three decades. RAS cycles from an active to inactive state by both intrinsic and GTPase-activating protein (GAP)-stimulated hydrolysis. The activated enzyme interacts with downstream effector...

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Библиографические подробности
Опубликовано в: :Biochemistry
Главные авторы: Moghadamchargari, Zahra, Huddleston, Jamison, Shirzadeh, Mehdi, Zheng, Xueyun, Clemmer, David E., Raushel, Frank M., Russell, David H., Laganowsky, Arthur
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196336/
https://ncbi.nlm.nih.gov/pubmed/31306575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00532
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