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Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry
Mutations in RAS are associated with many different cancers and have been a therapeutic target for more than three decades. RAS cycles from an active to inactive state by both intrinsic and GTPase-activating protein (GAP)-stimulated hydrolysis. The activated enzyme interacts with downstream effector...
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| Publicado en: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7196336/ https://ncbi.nlm.nih.gov/pubmed/31306575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00532 |
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