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Selective regulation of human TRAAK channels by biologically active phospholipids

TRAAK is an ion channel from the two-pore domain potassium (K(2P)) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity and selectivity of K(2P)4.1 towards lipids remains...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Schrecke, Samantha, Zhu, Yun, McCabe, Jacob, Bartz, Mariah, Packianathan, Charles, Zhao, Minglei, Zhou, Ming, Russell, David, Laganowsky, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746637/
https://ncbi.nlm.nih.gov/pubmed/32989299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00659-5
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