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Mechanism of misfolding of the human prion protein revealed by a pathological mutation
The misfolding and aggregation of the human prion protein (PrP) is associated with transmissible spongiform encephalopathies (TSEs). Intermediate conformations forming during the conversion of the cellular form of PrP into its pathological scrapie conformation are key drivers of the misfolding proce...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7999870/ https://ncbi.nlm.nih.gov/pubmed/33731477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019631118 |
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