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Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease‐associated T183A variant

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders associated with the misfolding and aggregation of the human prion protein (huPrP). Despite efforts into investigating the process of huPrP aggregation, the mechanisms triggering its misfolding remain elusive. A nu...

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Detalles Bibliográficos
Publicado en:Biomol NMR Assign
Main Authors: Sanz-Hernández, Máximo, De Simone, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7974147/
https://ncbi.nlm.nih.gov/pubmed/33590433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-021-10005-y
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