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Backbone NMR assignments of the C-terminal domain of the human prion protein and its disease‐associated T183A variant

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders associated with the misfolding and aggregation of the human prion protein (huPrP). Despite efforts into investigating the process of huPrP aggregation, the mechanisms triggering its misfolding remain elusive. A nu...

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Dettagli Bibliografici
Pubblicato in:Biomol NMR Assign
Autori principali: Sanz-Hernández, Máximo, De Simone, Alfonso
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7974147/
https://ncbi.nlm.nih.gov/pubmed/33590433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-021-10005-y
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