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Disulfiram Acts as a Potent Radio-Chemo Sensitizer in Head and Neck Squamous Cell Carcinoma Cell Lines and Transplanted Xenografts

The poor prognosis of locally advanced and metastatic head and neck squamous cell carcinoma (HNSCC) is primarily mediated by the functional properties of cancer stem cells (CSCs) and resistance to chemoradiotherapy. We investigated whether the aldehyde dehydrogenase (ALDH) inhibitor disulfiram (DSF)...

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Publicat a:Cells
Autors principals: Yao, Wenhao, Qian, Xu, Ochsenreither, Sebastian, Soldano, Ferrone, DeLeo, Albert B., Sudhoff, Holger, Oppel, Felix, Kuppig, Andreas, Klinghammer, Konrad, Kaufmann, Andreas M., Albers, Andreas E.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7999545/
https://ncbi.nlm.nih.gov/pubmed/33671083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10030517
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