Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper

Therapies for lung cancer patients initially illicit desirable responses, but the presence of hypoxia and drug resistant cells within tumors ultimately lead to treatment failure. Disulfiram (DSF) is an FDA approved, copper chelating agent that can target oxidative metabolic frailties in cancer vs. n...

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Publicat a:Free Radic Biol Med
Autors principals: Falls-Hubert, Kelly C., Butler, Aimee L., Gui, Kai, Anderson, Michael, Li, Mengshi, Stolwijk, Jeffrey M., Rodman, Samuel N., Solst, Shane R., Tomanek-Chalkley, Ann, Searby, Charles C., Sheffield, Val C., Sandfort, Vanessa, Schmidt, Hartmut, McCormick, Michael, Wels, Brian R., Allen, Bryan G., Buettner, Garry R., Schultz, Michael K., Spitz, Douglas R.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299833/
https://ncbi.nlm.nih.gov/pubmed/32032663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.01.186
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