Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper

Therapies for lung cancer patients initially illicit desirable responses, but the presence of hypoxia and drug resistant cells within tumors ultimately lead to treatment failure. Disulfiram (DSF) is an FDA approved, copper chelating agent that can target oxidative metabolic frailties in cancer vs. n...

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Publicado en:Free Radic Biol Med
Main Authors: Falls-Hubert, Kelly C., Butler, Aimee L., Gui, Kai, Anderson, Michael, Li, Mengshi, Stolwijk, Jeffrey M., Rodman, Samuel N., Solst, Shane R., Tomanek-Chalkley, Ann, Searby, Charles C., Sheffield, Val C., Sandfort, Vanessa, Schmidt, Hartmut, McCormick, Michael, Wels, Brian R., Allen, Bryan G., Buettner, Garry R., Schultz, Michael K., Spitz, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299833/
https://ncbi.nlm.nih.gov/pubmed/32032663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.01.186
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