Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper

Therapies for lung cancer patients initially illicit desirable responses, but the presence of hypoxia and drug resistant cells within tumors ultimately lead to treatment failure. Disulfiram (DSF) is an FDA approved, copper chelating agent that can target oxidative metabolic frailties in cancer vs. n...

詳細記述

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書誌詳細
出版年:Free Radic Biol Med
主要な著者: Falls-Hubert, Kelly C., Butler, Aimee L., Gui, Kai, Anderson, Michael, Li, Mengshi, Stolwijk, Jeffrey M., Rodman, Samuel N., Solst, Shane R., Tomanek-Chalkley, Ann, Searby, Charles C., Sheffield, Val C., Sandfort, Vanessa, Schmidt, Hartmut, McCormick, Michael, Wels, Brian R., Allen, Bryan G., Buettner, Garry R., Schultz, Michael K., Spitz, Douglas R.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299833/
https://ncbi.nlm.nih.gov/pubmed/32032663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.01.186
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