Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer

Despite recent advances, the treatment of head and neck squamous cell carcinoma (HNSCC) remains an area of high unmet medical need. HNSCC is frequently associated with either amplification or mutational changes in the PI3K pathway, making PI3K an attractive target particularly in cetuximab-resistant...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Klinghammer, Konrad, Politz, Oliver, Eder, Theresa, Otto, Raik, Raguse, Jan-Dirk, Albers, Andreas, Kaufmann, Andreas, Tinhofer, Ingeborg, Hoffmann, Jens, Keller, Ulrich, Keilholz, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566806/
https://ncbi.nlm.nih.gov/pubmed/33110476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27763
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