Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Immune checkpoints are emerging treatment targets, but mechanisms underlying checkpoint expression are poorly understood. Since alterations in DNA repair genes have been connected to the efficacy of checkpoint inhibitors, we investigated associations between methylation of DNA repair genes and CTLA4...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Rieke, Damian T., Ochsenreither, Sebastian, Klinghammer, Konrad, Seiwert, Tanguy Y., Klauschen, Frederick, Tinhofer, Inge, Keilholz, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342748/
https://ncbi.nlm.nih.gov/pubmed/27683114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12211
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