Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Immune checkpoints are emerging treatment targets, but mechanisms underlying checkpoint expression are poorly understood. Since alterations in DNA repair genes have been connected to the efficacy of checkpoint inhibitors, we investigated associations between methylation of DNA repair genes and CTLA4...

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Vydáno v:Oncotarget
Hlavní autoři: Rieke, Damian T., Ochsenreither, Sebastian, Klinghammer, Konrad, Seiwert, Tanguy Y., Klauschen, Frederick, Tinhofer, Inge, Keilholz, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342748/
https://ncbi.nlm.nih.gov/pubmed/27683114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12211
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