Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Immune checkpoints are emerging treatment targets, but mechanisms underlying checkpoint expression are poorly understood. Since alterations in DNA repair genes have been connected to the efficacy of checkpoint inhibitors, we investigated associations between methylation of DNA repair genes and CTLA4...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Rieke, Damian T., Ochsenreither, Sebastian, Klinghammer, Konrad, Seiwert, Tanguy Y., Klauschen, Frederick, Tinhofer, Inge, Keilholz, Ulrich
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342748/
https://ncbi.nlm.nih.gov/pubmed/27683114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12211
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