Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Immune checkpoints are emerging treatment targets, but mechanisms underlying checkpoint expression are poorly understood. Since alterations in DNA repair genes have been connected to the efficacy of checkpoint inhibitors, we investigated associations between methylation of DNA repair genes and CTLA4...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Rieke, Damian T., Ochsenreither, Sebastian, Klinghammer, Konrad, Seiwert, Tanguy Y., Klauschen, Frederick, Tinhofer, Inge, Keilholz, Ulrich
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342748/
https://ncbi.nlm.nih.gov/pubmed/27683114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12211
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