Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer

Despite recent advances, the treatment of head and neck squamous cell carcinoma (HNSCC) remains an area of high unmet medical need. HNSCC is frequently associated with either amplification or mutational changes in the PI3K pathway, making PI3K an attractive target particularly in cetuximab-resistant...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Klinghammer, Konrad, Politz, Oliver, Eder, Theresa, Otto, Raik, Raguse, Jan-Dirk, Albers, Andreas, Kaufmann, Andreas, Tinhofer, Ingeborg, Hoffmann, Jens, Keller, Ulrich, Keilholz, Ulrich
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566806/
https://ncbi.nlm.nih.gov/pubmed/33110476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27763
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