LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

Activating mutations in LRRK2 kinase causes Parkinson’s disease. Pathogenic LRRK2 phosphorylates a subset of Rab GTPases and blocks ciliogenesis. Thus, defining novel phospho-Rab interacting partners is critical to our understanding of the molecular basis of LRRK2 pathogenesis. RILPL2 binds with str...

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Bibliografiske detaljer
Udgivet i:Life Sci Alliance
Main Authors: Dhekne, Herschel S, Yanatori, Izumi, Vides, Edmundo G, Sobu, Yuriko, Diez, Federico, Tonelli, Francesca, Pfeffer, Suzanne R
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994366/
https://ncbi.nlm.nih.gov/pubmed/33727250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202101050
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