LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

Activating mutations in LRRK2 kinase causes Parkinson’s disease. Pathogenic LRRK2 phosphorylates a subset of Rab GTPases and blocks ciliogenesis. Thus, defining novel phospho-Rab interacting partners is critical to our understanding of the molecular basis of LRRK2 pathogenesis. RILPL2 binds with str...

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Vydáno v:Life Sci Alliance
Hlavní autoři: Dhekne, Herschel S, Yanatori, Izumi, Vides, Edmundo G, Sobu, Yuriko, Diez, Federico, Tonelli, Francesca, Pfeffer, Suzanne R
Médium: Artigo
Jazyk:Inglês
Vydáno: Life Science Alliance LLC 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994366/
https://ncbi.nlm.nih.gov/pubmed/33727250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202101050
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