A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Parkinson’s disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases, including Rab8A and Rab10. We show here that LRRK2 kinase interferes with primary cilia formation in cultured cells, human LRRK2 G2019S iPS cells and in the cortex of LRRK2 R1441C mice. Rab10 phosphorylation strengthens...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Dhekne, Herschel S, Yanatori, Izumi, Gomez, Rachel C, Tonelli, Francesca, Diez, Federico, Schüle, Birgitt, Steger, Martin, Alessi, Dario R, Pfeffer, Suzanne R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219843/
https://ncbi.nlm.nih.gov/pubmed/30398148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40202
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