Allostery governs Cdk2 activation and differential recognition of CDK inhibitors

Cyclin-dependent kinases (CDKs) are the master regulators of the eukaryotic cell cycle. To become activated, CDKs require both regulatory phosphorylation and binding of a cognate cyclin subunit. We studied the activation process of the G1/S kinase Cdk2 in solution and developed a thermodynamic model...

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Опубликовано в: :Nat Chem Biol
Главные авторы: Majumdar, Abir, Burban, David J., Muretta, Joseph M., Thompson, Andrew R., Engel, Tiffany A., Rasmussen, Damien M., Subrahmanian, Manu V., Veglia, Gianluigi, Thomas, David D., Levinson, Nicholas M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990704/
https://ncbi.nlm.nih.gov/pubmed/33526892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00725-y
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