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ALLOSTERY AND BINDING COOPERATIVITY OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE A BY NMR SPECTROSCOPY AND MOLECULAR DYNAMICS SIMULATIONS
The catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is an exquisite example of a single molecule allosteric enzyme, where classical and modern views of allosteric signaling merge. In this chapter, we describe the mapping of PKA-C conformational dynamics and allosteric signaling in the f...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3546502/ https://ncbi.nlm.nih.gov/pubmed/22607761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-398312-1.00012-3 |
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