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ALLOSTERY AND BINDING COOPERATIVITY OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE A BY NMR SPECTROSCOPY AND MOLECULAR DYNAMICS SIMULATIONS

The catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is an exquisite example of a single molecule allosteric enzyme, where classical and modern views of allosteric signaling merge. In this chapter, we describe the mapping of PKA-C conformational dynamics and allosteric signaling in the f...

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Bibliografische gegevens
Hoofdauteurs: MASTERSON, LARRY R., CEMBRAN, ALESSANDRO, SHI, LEI, VEGLIA, GIANLUIGI
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546502/
https://ncbi.nlm.nih.gov/pubmed/22607761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-398312-1.00012-3
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