Allosteric cooperativity in protein kinase A

Allosteric signaling in proteins requires long-range communication mediated by highly conserved residues, often triggered by ligand binding. In this article, we map the allosteric network in the catalytic subunit of protein kinase A using NMR spectroscopy. We show that positive allosteric cooperativ...

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Huvudupphovsmän: Masterson, Larry R., Mascioni, Alessandro, Traaseth, Nathaniel J., Taylor, Susan S., Veglia, Gianluigi
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206566/
https://ncbi.nlm.nih.gov/pubmed/18178622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709214104
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