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Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
Protein kinases undergo large-scale structural changes that tightly regulate function and control recognition by small-molecule inhibitors. Methods for quantifying the conformational effects of inhibitors and linking them to an understanding of selectivity patterns have long been elusive. We have de...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6304972/ https://ncbi.nlm.nih.gov/pubmed/30518564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811158115 |
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